Chrome is shifting from Manifest V2 to V3, "to improve the privacy, security, and performance of extensions", the result of which deprecates certain features that popular ad-blockers, including uBlock-Origin, rely on.
I find this very disappointing to read. For what it's worth, uBlock-origin asserts that it "is not an "ad blocker"; [rather,] it's a wide-spectrum content blocker".
The question for me is whether this change impacts "only" Chrome itself, or whether it also applies to Chromium-based browsers. Per the last paragraph here https://www.msn.com/en-us/news/technology/google-chrome-is-killing-one-of-the-most-popular-ad-blockers-around/ar-AA1oF7B1,
uBlock-Origin will still work in [Chromium-based] Edge. I currently use uBlock-O in Edge, Firefox, and PaleMoon.
People who want/need the actual Chrome browser can consider alternative extensions, such as uBlock-Origin-LITE, which meets Google's change to Manifest V3 https://chromewebstore.google.com/detail/ublock-origin-lite/ddkjiahejlhfcafbddmgiahcphecmpfh?
MalwareBytes Browser Guard is also impacted, see https://www.malwarebytes.com/blog/personal/2024/08/google-manifest-v3-and-malwarebytes-browser-guard?